Mechanisms of Sinomenine Nanoparticles in the Treatment of Breast Cancer Based on Network Pharmacology

This article mainly discusses the mechanism of SINOMENINE nanoparticles in treatment breast cancer by using network pharmacology method. TCMSP and Swiss Target Prediction databases were searched for target SINOMENINE. The was through GeneCards database. common targets both considered as treating cancer. software Cytoscape 3.7.1 used topological analysis visualization. DAVID GO enrichment analysis. A total 57 key obtained, which AKT1, MTOR, EGFR, NOS3, MAPK8, MMP9, etc. results pathway functional annotation show that involves protein phosphorylation positive regulation nitric oxidebiosynthetic process regulating Sphingolipid signaling pathway, Pathways cancer, Measles, Smallcell lung Focal adhesion, Insulin resistance. There are 10 major biological processes, including phosphorylation, signal transduction, negative apoptotic process, autophosphorylation. study not only initially revealed potential molecular SINOMENINE, but also provided a reference in-depth development